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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is commonly used for the bioanalysis of GLP-1 analogues and biomarkers, but the method development faces three challenges: High interference and low sensitivity Due to the low intestinal absorption and poor proteolytic stability in the gastrointestinal tract, drug concentrations of GLP-1 analogues following oral administration are generally low

GLP-1RAs are widely used in the treatment of type 2 diabetes (T2DM)

Theranostics 11 , 22472262 (2021)

J Comp Neurol (1999) 403:26180