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The STEP clinical trial program enrolled a majority-female population (approximately 75% in STEP-1), making it one of the more sex-representative obesity pharmacotherapy datasets available

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Weight loss program Semaglutide is usually the clearest first GLP-1 choice for people who want a well-studied weekly medication, strong appetite control, and a familiar clinical evidence base

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This apparent paradoxan early risk coupled with a potential long-term benefitdemanded a mechanistic explanation