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Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial
Resting heart-rate increase (530%): Modest average rise of a few bpm
Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting
Its role in glucose homeostasis and its application in diabetes treatment
H.ValentiL.HuY.-Y.et al (2024)
The compound demonstrates extended stability with a prolonged half-life, making it suitable for weekly intervals in research protocols
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