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Multiple anatomical and physiologic factors reduce oxygen diffusion into wound beds resulting in delayed healing 1-3

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Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003

Glutathione helps manage oxidative stress and its symptoms

Maintenance dose optimization Once reaching the initial target dose, assessment determines whether further increases benefit the protocol

Tschopp, J