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Maintaining gradual weight loss, adequate protein intake (RDA 0.8 g/kg daily, with higher intakes of 1.2-1.6 g/kg potentially beneficial during weight loss unless contraindicated by kidney disease), resistance exercise, and skin hydration may optimize skin adaptation during weight reduction

In conclusion, our understanding of adipocyte lipolysis has greatly increased over the past 50 years, and further work should uncover additional layers of regulation that can be targeted

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The condition typically develops slowly over months or years

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Conditions such as diabetes, neurological disorders, or other chronic illnesses might affect how you respond to these treatments