Conversely, in lean PCOS or those with a lighter metabolic load, GLP-1RAs typically yield smaller reductions, as baseline glucose and HOMA-IR levels are often within the normal range
It is also independently associated with cardiovascular morbidity and mortality
doi:10.1210/clinem/dgab359 3
In fact, several medical societies have issued statements advising against using compounded GLP-1 drugs outside of very specific shortage-related circumstances
Unlike BCTC, exendin 939 also mitigated both thermal and mechanical nociceptive behaviors in mice without inducing hyperthermia, indicating that it is a viable analgesic without the common adverse effects associated with existing pain management strategies, such as opioids and traditional TRPV1 antagonists 32,42,51,52,53
Patients with established cardiovascular disease Those with previous myocardial infarction, stroke, or peripheral arterial disease may benefit from the cardioprotective effects of certain GLP-1 receptor agonists, which include modest blood pressure reductions alongside other cardiovascular benefits
