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As of April 2026, the FDA has continued to remove various peptides from safety-risk lists, provided they are prescribed by licensed physicians and sourced from regulated facilities

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For comprehensive anti-aging goals, sermorelin is often considered the primary choice because: It aligns with natural hormone rhythms and sleep-based GH release It has a longer clinical history and prior FDA-approved status It supports sustained pituitary function over time Sleep improvement is typically rapid and pronounced However, ipamorelin offers advantages when anti-aging goals are focused on body composition, recovery, and maintaining a clean hormonal profile