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Impaired -ketoglutarate dehydrogenase (KGDH) activity reduces NADH production, disrupting respiratory chain function and ATP synthesis

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Additionally, the biological activities of phenolic compounds can be influenced by their metabolites [279,280,281]

The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity