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The glycine amino acid attached to the magnesium also acts as an inhibitory neurotransmitter, providing additional calming effects for the nervous system, which is highly beneficial for patients experiencing POTS, anxiety, or sleep disturbances

Awasthi S, Bajpai KK, Piper JT, et al

Senescence is a major contributor to aging and the development of cardiovascular disease (123), and sirtuin-1 expression is required for metformin to protect endothelial cells against hyperglycemia-induced senescence (110)

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The dose is built up slowly over 16 weeks: 0.25 mg in weeks 1 to 4, then 0.5 mg, 1.0 mg, 1.7 mg, and from week 17 the maintenance dose of 2.4 mg once a week