Reaching for something in my wardrobe became a gamble: 50% chance it would fit, 25% it would be too baggy, and another 25% it was from so long ago I no longer liked it
Here we report results from the randomized, double-blind, placebo-controlled, multicenter phase 2 EMBRAZE trial, which evaluated the efficacy and safety of apitegromab in adults with overweight or obesity receiving incretin mimetic therapy for pharmacologic weight management
Clinical trials reveal weight loss results of up to 20% of body weight when combined with lifestyle changes, positioning semaglutide as one of the most potent weight loss medications available
When contents are delayed in moving from the stomach to the small intestines, this is referred to as gastroparesis
However, the precise molecular mechanisms, temporal dynamics, and cell-type specificity of this interplay remain poorly understood
Some individuals may experience greater benefits, particularly those with insulin resistance or polycystic ovary syndrome (PCOS), though responses remain highly variable
