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4 Immune and metabolic crosstalk in the regulation of ferroptosis Beyond metabolic changes, immune components significantly influence ferroptotic events in OA

Antioxidant - a compound that prevents or repairs the damage caused by reactive oxygen species Antioxidant enzymes - enzymes that contribute to neutralizing atoms or molecules capable of damaging essential cell constituents Artery (adj: arterial) - a muscular-walled blood vessel that carries blood away from the heart Diuretic - an agent that increases the formation of urine by the kidneys, resulting in water loss from the individuals using the diuretic Inverse association - a relationship between two variables in which they move in opposite directions Nitric oxide - a gaseous signaling molecule

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doi: 10.3390/ijms242316906 77 Santa CruzAMendes-FriasAAzarias-da-SilvaMAndrSOliveiraAIPiresOet al

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