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*Glutathione decline reference: Lang et al., J Lab Clin Med circulating glutathione levels decline approximately 30% by age 65 in healthy adults compared to younger adults.
Additionally, a Phase 2 open-label extension study evaluates long-term safety and efficacy of zasocitinib in 183 participants aged 1876 with both UC and CD who demonstrated clinical or symptomatic response at week 52 of their parent trials, focusing on treatment-emergent AEs and clinically significant changes in vital signs, laboratory values, and ECG over 108 weeks of continued treatment, having started in May 2025 with completion expected in December 2029 (NCT06764615)
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Body Composition Shifts As you lose weight, a portion of that loss is lean mass, muscle, bone density, organ tissue
& Di Stefano, A