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Biochemistry 45 , 49834990 (2006)
Findings suggest that GLP-1 RAs are associated with reduced risk of MACE, and MI among people with OW/OB, but they were driven by studies with established CVD at baseline
Food and Drug Administration approval of semaglutide (Ozempic) to reduce the risk of kidney disease progression, kidney failure, and cardiovascular death in adults with type 2 diabetes (T2D) and chronic kidney disease (CKD), its impact on clinical practice is becoming increasingly evident
Several candidates are advancing through clinical development, including orforglipron, currently in Phase III trials for obesity and type 2 diabetes
Less pressure on the digestive system and a quieter appetite play into this, too