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Treatment with these drugs has shown to be effective in decreasing tumor size, but the resistance is a problem in the management of melanoma

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Anterior ischaemic optic neuropathy (AION) is defined as neuropathy involving the 1mm segment of the optic disc, and results in visible disc swelling

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Additionally, the gel started forming within minutes of mixing, ensuring sufficient time for the injection while minimising spread at the injection site, so that the depot is small enough to be comfortable and inconspicuous