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11 The SELECT trial showed a 20% reduction in the risk of these events in adults with obesity and cardiovascular disease but no prior history of diabetes

LDL cholesterol reductions of approximately 20% represent clinically meaningful decreases in atherosclerotic risk

GLP-1 receptor agonists work by increasing the levels of the hormone GLP-1 in the body, which helps to increase the bodys sensitivity to insulin and reduce hunger

Additionally, it has been suggested that GIPR agonists and antagonists might target different CNS receptor populations, with evidence showing that acylated peptide GIPR agonists act on GABAergic neurons to further reduce food intake and body weight when combined with GLP-1R agonists in mice 39,40

How to perform a meta-analysis with R: a practical tutorial

Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes