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2020 Apr;34(4):107520

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Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

Further in vivo studies have also found that caffeine inhibited the activation of hepatic stellate and sinusoidal endothelial cells, which was reversed by CPA (1 mg/kg/day, i.p.) and GCS21680 (0.5 mg/kg/day, i.p.) (Figure 3) (Hsu et al., 2015)

Nutrition, physical activity, sleep, stress management, social connection and avoiding harmful substances all work together to improve metabolic health