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Indeed, there is a growing body of evidence that suggests that in addition to being a consequence of these chronic diseases, oxidative stress could also be a key mediator in their progression [44,45,46]

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Jensterle et al., 2020)

All five trials met the primary objective of excluding an increased risk of cardiovascular disease in patients treated with DPP-4 inhibitors, however, none were associated with any cardiovascular benefit ( GLP-1 Receptor Agonists The cardiovascular safety of GLP-1RA have been assessed in seven clinical trials enrolling 60,090 patients ( The differences in cardiovascular outcomes between the various GLP-1RA currently available for the treatment of patients with T2DM may be the result of differences in study design or patient populations