The expression of PGC1 and OXPHOS activities are increased in the long-living Ames dwarf mice (lack of GH, prolactin, and thyroid-stimulating hormone), demonstrating a negative effect of GH on mitochondrial biogenesis (Westbrook et al., 2009
Through a multitude of mechanisms including the inhibition of cell growth, induction of cell cycle arrest and apoptosis, and interference with crucial signaling pathways such as the MALAT1-Wnt/-catenin axis, GA exhibits substantial potential in the therapy of HCC
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When this process is damaged, some electrons would leak and lead to ROS production (Mani et al., 2020
Therefore, it is necessary to develop standardised operational protocols to obtain comparable and homogeneous data among different scientific studies
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