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Contrave has more significant interaction potential, particularly with MAO inhibitors, seizure medications, and other drugs affecting serotonin or norepinephrine levels

Xu, Y., Buikema, H., van Gilst, W

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Strong Cardiovascular & Renal Protection Evidence continues to grow: - Reduced risk of major adverse cardiovascular events (MACE) - Lower incidence of heart failure and atrial fibrillation - Protective effects in kidney disease and high-risk populations These benefits often extend beyond weight loss alone, suggesting direct biological effects