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10.1371/journal.pone.0097554 [DOI] [PMC free article] [PubMed] [Google Scholar] Kristensen S

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Second, we applied a series of sensitivity analyses and set a Bonferroni-corrected threshold for multiple testing, followed by colocalization analyses, to boost the reliability and robustness of the results

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The tri-agonist architecture requires intact tertiary folding to maintain receptor affinity across all three pathways, and even brief thermal stress disrupts hydrogen bonding that holds the peptide's active conformation

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