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Mean placebo-subtracted weight loss of 5.8 kg from randomization with liraglutide 3.0 mg was 1.5 kg more than with sibutramine in similar 1-year trials

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Compared to other anti-obesity medications (e.g., dulaglutide and semaglutide) administered over the same duration, tirzepatide demonstrated a superior reduction in body fat compartments, including total fat mass, VAT, and waist circumference [63]

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