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Gerein, V

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After single IM administrations of doses 20, 100, or 500 g/kg, the peak time (T max ) of each dose was 3 min

Given that PI3K-AKT signaling regulates key downstream targets involved in cytokine production, cell survival, fibroblast-to-myofibroblast transition, and tissue remodeling in chronic airway diseases [39, 40], the observed inhibition of pathway phosphorylation provides a plausible explanation for the reduced airway inflammation and preservation of alveolar architecture in our model