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Topical glutathione has limited absorption through the skin

First, it reduces damage from the sun and pollution

While SLU-PP-332 mimics certain metabolic adaptations of exercise, it does not replace all benefits of physical activity, such as mechanical stress on bones and muscles, neuromuscular coordination, or psychological benefits

doi: 10.1016/j.cpt.2025.02.006 67 AliSSAl-TohamyRAl-ZahraniMBadrASunJ

The transpeptidase uses glutathione as a substrate and transfers -Glu-Cys moieties on glutathione or (-Glu-Cys)n-Gly to form phytochelatins ((-Glu-Cys)n-Gly with n between 2 and 10)

Supplementation with antioxidants or increasing their intake through diets can help to reduce the damage caused by ROS