hypothyroid and semaglutide with Underactive Thyroid: Safety & Provider Guidance – PlexusDx Semaglutide and Hypothyroidism | Nulevel

Cells, 10(6), 1343

There are several limitations to this literature review

A Cleveland Clinic study found that cost and side effects were among the top reasons people said they discontinued them

Traditional GLP-1 weight loss drugs like Wegovy (semaglutide) or Mounjaro/Zepbound (tirzepatide) often result in muscle loss, which can adversely affect overall health outcomes

In addition, it will be of interest to understand whether the carnitine shuttle plays a role in compensating for ACLY and ACSS2 under conditions such as high fat diet, in which both enzymes are suppressed in adipose tissue 43

[1] Peptides and Gut Microbiome The gut microbiome is a complex and dynamic ecosystem composed of bacteria, viruses, fungi, and other microorganisms that interact closely with host physiology