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The 2022 FDA compounding restriction eliminated the previously available pathway through compounding pharmacies, narrowing the legal access routes further

Some research links long-term, high-dose metformin to a higher rate of diabetic peripheral neuropathy, while other studies find no clear difference in nerve symptoms between metformin users who are B12 deficient and those who are not

Some do, by design

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Unlike many peptides, it holds up in acidic environments and at room temperature for short periods, which is part of why it works both as an injectable and, in some forms, orally