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In addition, phosphorylation of two further serine residues (Ser100 and Ser511) by PKA mediates the recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in an inactivated state by preventing dephosphorylation of phospho-Ser495

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Activation of the mineralocorticoid receptor drives sodium retention and promotes renal inflammation, oxidative stress, and fibrosis, accelerating injury in diabetic kidney disease (DKD)

IGF-1 LR3 promotes protein synthesis and muscle hypertrophy IGF-1 LR3 induces a high rate of cell proliferation (hyperplasia) and division due to remaining in the bloodstream for much longer than regular IGF-1, with the effect of increasing muscle cells

10.1016/S0895-4356(98)00071-7

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