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2 Smart global development design The Japanese cohorts add: early ethnic sensitivity data Asia registration readiness broader dose confidence smoother global Phase III planning later Very smart global architecture

Acknowledgements Not applicable Funding This research was supported by the Ministry of Science, Education and Sports, Republic of Croatia (grant number 108-1083570-3635)

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Brief virtual consultations may not provide the thorough medical evaluation that in-person visits offer, potentially missing contraindications or underlying health issues that would make GLP-1 use dangerous

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