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doi:10.1016/j.jaad.2013.09.036 Yang, K., Y

Glutathione helps "recharge" Vitamin C after it has neutralized a free radical, and Vitamin C helps maintain glutathione levels by protecting it from being oxidized too quickly

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Moreover, erythrocytes express calpain-1 [110], a Ca 2+ -dependent protease that may contribute to the breakdown of the cytoskeleton during eryptosis

To establish a robust mechanistic frameworkparticularly concerning mitochondrial bioenergetics and redox homeostasis, highly relevant in vivo and in vitro preclinical models were also deemed eligible for inclusion