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Bioorg Med Chem 94:117479

Screen 2 GI burden: Does it cause nausea or diarrhea

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At the barrier level, aberrant intercellular junctional proteins (tight-junction, adherens-junction, and cytoskeleton-associated proteins) [9] and increased programmed cell death of intestinal epithelial cells [10] have been identified as key pathogenic mechanisms

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Filamentous gls1 promotes ros-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis