No approval for either
In particular, GLP-2 increases fasting plasma triglyceride level, very low-density lipoprotein (VLDL) production and hepatic lipogenesis, thereby leading to hepatic steatosis 7
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Recommended articles Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review Alorfi NM, Algarni AS Clinical Pharmacology: Advances and Applications 2022, 14:61-67 Published Date: 3 August 2022 Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations Chao AM, Tronieri JS, Amaro A, Wadden TA Drug Design, Development and Therapy 2022, 16:4449-4461 Published Date: 29 December 2022 Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies Demirbilek H, Vuralli D, Haris B, Hussain K Diabetes, Metabolic Syndrome and Obesity 2023, 16:259-273 Published Date: 27 January 2023 The Characteristics, Mechanisms and Therapeutics: Exploring the Role of Gut Microbiota in Obesity Zhuang Z, Zhou P, Wang J, Lu X, Chen Y Diabetes, Metabolic Syndrome and Obesity 2023, 16:3691-3705 Published Date: 20 November 2023 The Body weight Reducing Effects of Tirzepatide in People with and without Type 2 Diabetes: A Review on Efficacy and Adverse Effects Jensen TL, Brnden A, Karstoft K, Sonne DP, Christensen MB Patient Preference and Adherence 2024, 18:373-382 Published Date: 8 February 2024
Studies show GLP-1s help decrease weight, improve metabolic complications, lower flares and stiffness, and may slow joint damage when combined with DMARDs or biologics
Tirzepatide acts on both GIP and GLP-1 pathways
