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A separate prespecified SELECT analysis confirmed that semaglutide reduced cardiovascular events irrespective of baseline HbA1c or change in HbA1c, including in normoglycemic patients and in patients who showed no glycemic improvement whatsoever

A total of 8032 (22.9%) patients had switched GLP-1 receptor agonist, with the most common drug switch being from liraglutide to semaglutide ( n = 5839

He et al., 2025

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