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What has been slower to emerge is a framework that recognizes these not as independent problems but as coordinated consequences of a single underlying disruption: the withdrawal of hormonal signals that had, for decades, been quietly governing cellular energy regulation, inflammatory tone, and tissue maintenance throughout the body
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A., & McNaughton, L
The proposed mechanisms range from well-validated (FDA-approved GLP-1 agonists for weight loss) to highly speculative (epitalon, thymosin alpha-1, MOTS-c) with limited or no human clinical validation
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