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Despite these advances, important questions remain regarding the long-term durability of benefits, the degree of kidney protection independent of glycemic and weight effects, and the optimal integration of these therapies into routine care

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Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]

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