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Pro-opiomelanocortin (POMC) and cocaine- and amphetamine-related transcript (CART) neurons are first-order anorexigenic neurons

However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

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Certain people are at greater risk for deficiency because of things like diet, lifestyle, and prescription medications

The study also confirmed that AOD9604 works by inhibiting fat synthesis in liver and fat cells, providing additional mechanistic insight into how the peptide promotes metabolic health

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