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Epub 2024 Nov 5

Clinical data from large cancer cohorts further support the presence of dysregulated cholesterol biosynthesis in MSS CRC [5]

And this wasnt and isnt about weight, per se: I just wanted to feel good, and I never did

Thal LJ, Carta A, Clarke WR, et al

In trials with secondary endpoints, such as STEP 9 [38], semaglutide also resulted in significant improvements in obesity-related comorbidities, including osteoarthritis-related pain and rates of reversion to normoglycaemia, further underscoring its broad clinical utility

First, most studied is not the same as proven to work. Second, evidence in a specific clinical population (for example, premenopausal women with a diagnosed desire disorder) does not automatically transfer to a healthy person, a different sex, or a different age group