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has synthesized carboxy-benzimidazoles acting as glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of arthritis, diabetes, eating disorders, macular degeneration, myocardial infarction, nonalcoholic steatohepatitis, sleep apnea and Parkinson's disease, among others

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TNF- plays a crucial role in the pathogenesis of inflammatory diseases, including HS, as it promotes the expression of nuclear factor kappa B (NF-B), thereby exacerbating inflammation [54,55]