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Treatment with 1 mM GSH led to the upregulation of PR1 , PR10 , and Cyp15a in sym33-3 mutants (Figure 10)

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Importantly, AOD-9604 does not bind to growth hormone receptors or stimulate IGF-1 production, which distinguishes it from full-length human growth hormone

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EMFs (Low-Frequency) amplify this process, driving mitochondrial membrane depolarization and ROS overproduction, which synergizes with iron-dependent lipid peroxidation to potentiate ferroptosis