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Mechanistically, SWT activates the Nrf2/HO-1 pathway, boosts antioxidant enzyme expression such as SOD, and attenuates lipid peroxidation, while simultaneously promoting angiogenesis via the STAT3/HIF-1/VEGF cascade, collectively improving follicular microenvironment and reproductive capacity [161]

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Interestingly, other studies have inhibited TGF receptor kinase activity, which reduced SMAD3 activity, and observed elevated claudin-5 expression

In these mice, administration of tamoxifen allows nuclear transport of the Cre-recombinase resulting in deletion of the loxP-flanked stop sequence and permanent expression of YFP (Figure 1)