8 Generally, these side-effects are self-limited, occur more commonly shortly after drug initiation or during dose escalation periods, and lessen after a few weeks of GLP-1 RA administration
Individuals uncomfortable with self-injection may achieve excellent results with oral administration alone
Wei J, Chen J, Wei X et al (2022) Long-term remission of type 2 diabetes after very-low-calorie restriction and related predictors
Although these therapies offer distinct mechanisms, their clinical translation remains limited by safety concerns, poor translatability, and inadequate weight-loss efficacy as monotherapies
Increasing protein intake while taking GLP-1 drugs for weight loss could help prevent muscle loss, according to a new study
Causal relationships among GLP-1RA exposure, peripheral taste-pathway modulation, central reward-circuit activity, altered liking, reduced wanting, and long-term dietary behaviour remain incompletely established, and alternative explanations such as nausea-related aversion, delayed gastric emptying, altered satiety, expectancy effects, dietary compensation, medication adherence, and psychological or behavioural moderators should also be considered
