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The Difference Between Supplements and Foods There is a big difference between supplementing any of the above nutrients and getting a steady supply of them from the diet

Standard Concentration in Commercial Preparations Most B12 shots have 1,000 mcg/mL

Unlike tablets, which have to pass through your digestive system, an injection goes straight into the bloodstream

Source: However, not all peptides are regulated

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People with GI disorders like Crohns syndrome and celiac disease are often unable to break down and absorb dietary B12 and oral B12 supplements, leaving them deficient