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Concurrently, pivotal metabolic enzymes within the amino acid synthesis pathway, including glutamate-oxaloacetate transaminase 1 (GOT1), glutamate-pyruvate transaminase 2 (GPT2), pyrrolidine-5-carboxylic acid reductase 1 (PYCR1), and phosphoserine aminotransferase 1 (PSAT1), demonstrated increased expression [214]

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Additionally, RT-qPCR indicated that ferrostatin-1-induced inhibition of ferroptosis significantly reversed IL-1-induced decrease in mRNA expression of SLC7A11 and GPX4 in ECs and decreased mRNA expression of ACSL4 (Fig

The molecular mechanisms by which the disruption of the cell redox state plays a role in the pathogenesis of GO, as well as the potential beneficial effect of other antioxidant agents in patients with GO, are largely discussed in another review article in this issue of the journal