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Looking forward, subsequent research endeavors must emphasize biomarker-driven clinical trials that amalgamate neurotrophin concentrations, inflammatory biomarkers, and neurotransmitter metabolites to clarify mechanistic pathways and delineate patient cohorts that are most likely to derive therapeutic benefits from each botanical intervention

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Such studies have found that select deficiency in pantothenic acid causes demyelination (destruction or loss of the myelin sheath) and peripheral nerve damage (13)

GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes (14)