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Metabolic abnormalities yield menstrual disorders and ovulatory infertility via perturbed feedback cycles, persistently elevated low-grade inflammation, and aberrant steroidogenesis

, chronic fatigue and neurological symptoms observed in the first three weeks of illness can be a predictive factor for cognitive disorders (43)

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Methods Cell lines Spodoptera frugiperda 9 ( Sf 9) (Invitrogen) and High Five insect cells (Expression Systems) were cultured in ESF 921 serum-free medium (Expression Systems) at 27 C and 120 rpm