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Disruptions in these metabolic pathways, whether due to genetic mutations, hepatic dysfunction, or altered bile composition, lead to bilirubin supersaturation in bile, a key factor in gallstone pathogenesis

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Interestingly, although mammalian GR somewhat resembles the TrxR domain of SmTGR, the GR domain of SmTGR has the fold of Trx and is appended to the N-terminus of the TrxR core of SmTGR, containing the C28-C31 pair (Figure 1)

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