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Ethics declarations Ethics approval and consent to participate The animal protocol for this study was approved by the Institutional Animal Care and Use Committee of Huazhong Agricultural University, China (HZAURA-2025-0001)

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LDHA is involved in the conversion of pyruvate into lactate and therefore could be accumulated in the extracellular space

50 Epidemiology of ASD Over the past two decades, the prevalence of ASD reported worldwide has been steadily increasing

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