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It is difficult to determine whether our findings are the result of increased flux from a synthesizing enzyme, decreased flux toward a consuming enzyme, or alteration in transport of a metabolite into or out of cells or tissues

Over time, this inconsistency affected the results

In consequence, acylcarnitines constitute an appreciable component of the tissue carnitine pool, and tissue and plasma concentrations of carnitine and acylcarnitines are together maintained within relatively narrow limits by a variety of mechanisms, which influence in turn innumerable aspects of carbohydrate and lipid metabolism, including the regulation of insulin secretion by pancreatic -cells and the determination of tissue insulin sensitivity

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However, it is possible to revert this reaction and convert L-carnitine back into ALCAR, and this frequently occurs in the cell as part of normal metabolism