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Such endothelium protection may set up conditions in which endothelial sprouting and maturation may proceed

doi: 10.12659/MSM.926039 183 ZhuL.XuL.-Z.ZhaoS.ShenZ.-F.ShenH.ZhanL.-B

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Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1

Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a Western-style diet by increasing PPAR and expression and reducing TC, MMP-9, and Cat S levels

In this context, carriers of apolipoprotein 4 (APOE4) allele, a major risk factor for AD, present with pericyte degeneration and associated BBB breakdown [42], which has been recently associated with cognitive decline, independent of AD pathology [43]