Other neuroprotective mechanisms potentially involved in the treatment of cognitive disorders as well as cerebrovascular disease and epilepsy suggest that GLP-1RAs can enhance the viability of neurons and restore neurite outgrowth by stimulating neurotrophic factors, thus increasing subventricular zone progenitor cells, decreasing apoptosis and the level of pro-inflammatory factors, and strengthening the bloodbrain barrier 37
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While there was a substantial increase over the ten-year period between 2012 and 2022, some evidence indicates that utilization has only continued to rise over the last two years, beyond the most recent claims data available
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However, the role of GLP-1 RAs in psychiatric outcomes, particularly in depression or anxiety disorder, presents a mixed picture