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You may feel disheartened by the seeming lack of control over your body, but know that you are not alone in this perplexing and frustrating experience

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, more recently, obesity

To view a copy of this license, visit About this article Cite this article Xin, Z., Pu, L., Gao, W

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

Clinical guidelines support GLP-1 prescribing for individuals with a BMI of 30 or higher, or a BMI of 27 with weight-related conditions like hypertension or type 2 diabetes

But all too often, drugs that show promise in experimental animals simply dont perform very well once theyre tested in humans