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Quick Answer: Lack of results with semaglutide at lower doses typically reflects insufficient time at therapeutic levels, subtherapeutic dosing, or individual variability requiring dose escalation
"The study found a significant difference between the two groups, with an estimated treatment ratio of 1.13 (95% CI 1.061.21
Only 503B compounders are routinely inspected by the FDA and subject to CGMP regulations
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Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment